Analysis of 24 Patients with Carcinoma of Unknown Primary Site

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Management of patients with cancer of unknown primary site.

Cancer of unknown primary site represents approximately 3% to 5% of all new cancer diagnoses. Adenocarcinomas account for 60% of all unknown primary cancers and poorly differentiated carcinomas or adenocarcinomas, for 30%. Historically, the prognosis for most patients with unknown primary tumors has been poor, with survival often less than 6 months from diagnosis. Recent advances in diagnostic ...

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Phase II trial of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site.

BACKGROUND The purposes of this study were to evaluate efficacy and toxicity of the combination of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site (CUP). METHODS Patients with CUP received carboplatin AUC 5 mg/mL a minute intravenously Day 1, gemcitabine 1000 mg/m(2) intravenously Days 1 and 8, and capecitabine 1600 mg/m(2) orally in divided doses...

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Pericardial effusion in a dog concurrent with carcinoma of unknown primary origin

Background: Pericardial effusion (PE) due to secondary metastasis has rarely been reported in dogs. Case description: This case describes clinical signs and further diagnostics regarding metastatic carcinoma of unknown primary origin (CUP) in refractory PE of a dog. Findings/treatment and outcome: A nine-year-old, castrated mal...

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Carcinoma of unknown primary site (CUP): Outcomes in patients with a colorectal molecular profile treated with site-specific chemotherapy.

3563 Background: Molecular tumor profile assays (MTP) may predict the primary site of origin in CUP, but the impact of site-specific therapy on outcomes is undefined. Accurate identification of CUP patients (pts) with a colorectal site of origin would be expected to improve treatment results by directing the use of colorectal cancer regimens rather than empiric CUP regimens. METHODS We identi...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2013

ISSN: 0923-7534

DOI: 10.1093/annonc/mdt459.33